The antifungal drug primobolan depot cycle for topical application, which has a broad spectrum of antifungal activity. At low concentrations terbinafine has fungicidal activity against dermatophytes . Activity against yeast fungi, depending on their type, may be a fungicidal or fungistatic.Terbinafine specifically alters the early stage of the biosynthesis of sterols, occurring in fungi. This leads to a deficiency of ergosterol and to an intracellular accumulation of squalene, which causes death of fungal cells. Terbinafine action effected by the enzyme squalene epoxidase inhibiting located on the cell membrane of the fungus.Terbinafine has no primobolan depot cycle effect on the cytochrome P450 system in humans and, therefore, the metabolism of hormones or other drugs.
Pharmacokinetics. When applied topically absorption – less than 5% has little systemic effect.
Indications. Prevention and treatment of fungal infections of the skin, including foot mycoses ( “mushroom” of the foot), jock itch (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis), caused by such dermatophytes as by Trichophyton (including , T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum.
Colorful lichen (Pityriasis versicolor), called Pityrosporum orbiculare (also known as Malassezia furfur).
Contraindications. Hypersensitivity primobolan depot cycle to terbinafine or any of the inactive ingredients included in the formulation.
Precautions: . Liver and / or kidney failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease, children’s age (lack of sufficient clinical experience) .Beremennost and lactation has not been detected in experimental studies of the teratogenic properties of terbinafine. So far no reports about any developmental defects in the application of Lamisil. However, as clinical experience with terbinafine in pregnant women is very limited, it should be used only on strict conditions.
Terbinafine is excreted in breast milk. However, in the case of nursing mother Lamisil spray or solution is absorbed through the skin a small amount of the active substance, so primobolan depot cycle an adverse effect on the infant is unlikely.
Dosage and administration. Outwardly.
Adults. Lamisil spray or solution can be used one or two times a day, depending on indications. Before using the product, thoroughly clean and dry the affected area. The preparation was sprayed (spray) or coated (solution) to the affected area in an amount sufficient for a thorough wetting and, moreover, is applied to the surrounding diseased sites as well as intact skin. With extensive fungal lesions of the body is recommended to use a spray 30 ml.
Treatment duration and frequency of use of the drug:
ringworm of the body, legs: 1 week; 1 time per day
tinea pedis: 1 week; 1 time per day
pityriasis versicolor: 1 week; 2 times per day
Dosage Lamisil spray or solution in elderly patients is not different from the above.
Use of terbinafine spray or solution in children. Experience with Lamisil spray or solution in children is limited, and therefore the administration is not recommended in children.
Side effects. In the field application primobolan depot cycle of the drug can be redness, itching or burning. Allergic reactions.
Overdose. No cases of overdose have been reported. If accidentally Lamisil spray or solution is ingested, it is possible to expect development of the same side effects as an overdose of Lamisil tablets (headache, nausea, epigastric pain and dizziness). It should also take into account the content of ethanol in the formulation (23.5%).
Treatment: activated charcoal, if necessary – symptomatic supportive therapy.
Interactions. Any drug interactions for primobolan depot cycle Lamisil spray or no known solution.
Special instructions. Reducing the severity of clinical manifestations are usually noted in the first days of treatment. In the case of irregular or premature treatment termination there primobolan depot cycle is a risk of recurrence of infection. In the event that after a week of treatment shows no sign of improvement, must verify the diagnosis.
Caution must be exercised when applying Lamisil on damaged skin, as alcohol can cause irritation.
Lamisil spray or solution is designed for external use only. Avoid getting it in your eyes, as it may cause irritation. In case of accidental contact with the drug in the eyes, they should immediately wash with running water, and in the case of persistent phenomena of irritation consult a doctor.
If the drug was accidentally introduced into the respiratory tract by inhalation, that in case of any symptoms, and primobolan depot cycle especially when they are persistent saving, you must consult your doctor.
With the development of allergic reactions need to stop the drug.