primobolan depot cycle

The antifungal drug primobolan depot cycle for topical application, which has a broad spectrum of antifungal activity. At low concentrations terbinafine has fungicidal activity against dermatophytes . Activity against yeast fungi, depending on their type, may be a fungicidal or fungistatic.Terbinafine specifically alters the early stage of the biosynthesis of sterols, occurring in fungi. This leads to a deficiency of ergosterol and to an intracellular accumulation of squalene, which causes death of fungal cells. Terbinafine action effected by the enzyme squalene epoxidase inhibiting located on the cell membrane of the fungus.Terbinafine has no primobolan depot cycle effect on the cytochrome P450 system in humans and, therefore, the metabolism of hormones or other drugs.

Pharmacokinetics. When applied topically absorption – less than 5% has little systemic effect.

Indications. Prevention and treatment of fungal infections of the skin, including foot mycoses ( “mushroom” of the foot), jock itch (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis), caused by such dermatophytes as by Trichophyton (including , T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum.

Colorful lichen (Pityriasis versicolor), called Pityrosporum orbiculare (also known as Malassezia furfur).

Contraindications. Hypersensitivity primobolan depot cycle to terbinafine or any of the inactive ingredients included in the formulation.

Precautions: . Liver and / or kidney failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease, children’s age (lack of sufficient clinical experience) .Beremennost and lactation has not been detected in experimental studies of the teratogenic properties of terbinafine. So far no reports about any developmental defects in the application of Lamisil. However, as clinical experience with terbinafine in pregnant women is very limited, it should be used only on strict conditions.

Terbinafine is excreted in breast milk. However, in the case of nursing mother Lamisil spray or solution is absorbed through the skin a small amount of the active substance, so primobolan depot cycle an adverse effect on the infant is unlikely.

Dosage and administration. Outwardly.

Adults. Lamisil spray or solution can be used one or two times a day, depending on indications. Before using the product, thoroughly clean and dry the affected area. The preparation was sprayed (spray) or coated (solution) to the affected area in an amount sufficient for a thorough wetting and, moreover, is applied to the surrounding diseased sites as well as intact skin. With extensive fungal lesions of the body is recommended to use a spray 30 ml.

Treatment duration and frequency of use of the drug:
ringworm of the body, legs: 1 week; 1 time per day
tinea pedis: 1 week; 1 time per day
pityriasis versicolor: 1 week; 2 times per day

Dosage Lamisil spray or solution in elderly patients is not different from the above.

Use of terbinafine spray or solution in children. Experience with Lamisil spray or solution in children is limited, and therefore the administration is not recommended in children.

Side effects. In the field application primobolan depot cycle of the drug can be redness, itching or burning. Allergic reactions.

Overdose. No cases of overdose have been reported. If accidentally Lamisil spray or solution is ingested, it is possible to expect development of the same side effects as an overdose of Lamisil tablets (headache, nausea, epigastric pain and dizziness). It should also take into account the content of ethanol in the formulation (23.5%).

Treatment: activated charcoal, if necessary – symptomatic supportive therapy.

Interactions. Any drug interactions for primobolan depot cycle Lamisil spray or no known solution.

Special instructions. Reducing the severity of clinical manifestations are usually noted in the first days of treatment. In the case of irregular or premature treatment termination there primobolan depot cycle is a risk of recurrence of infection. In the event that after a week of treatment shows no sign of improvement, must verify the diagnosis.

Caution must be exercised when applying Lamisil on damaged skin, as alcohol can cause irritation.

Lamisil spray or solution is designed for external use only. Avoid getting it in your eyes, as it may cause irritation. In case of accidental contact with the drug in the eyes, they should immediately wash with running water, and in the case of persistent phenomena of irritation consult a doctor.

If the drug was accidentally introduced into the respiratory tract by inhalation, that in case of any symptoms, and primobolan depot cycle especially when they are persistent saving, you must consult your doctor.

With the development of allergic reactions need to stop the drug.

methenolone enanthate side effects

The pharmacological effect of the drug due methenolone enanthate side effects to the properties that make up the active components – lignin and lactulose.Hydrolysis lignin – a natural enterosorbent consisting of the components of the hydrolysis products of wood, has high sorption activity and nonspecific detoxification effect. It binds in the intestines and excrete pathogenic bacteria and bacterial toxins, drugs, heavy metals, alcohol, allergens and excess of certain metabolic products, including bilirubin, cholesterol, histamine, serotonin, urea, and other metabolites that are responsible for the development of endogenous toxicosis. Non-toxic, not absorbed, completely removed from the intestine within 24 hours. Hydrolysis of lactulose in the colon formed organic acids – lactic, acetic and formic inhibit the growth of pathogenic microorganisms and thereby reduce the production of nitrogen methenolone enanthate side effects containing toxic substances. The described process leads to an increase in osmotic pressure within the lumen of colon and stimulate peristalsis.Integrated effect of the drug is aimed at normalizing microbiocenosis colon and reducing the intensity methenolone enanthate side effects of endogenous toxic states.

 

Contraindications

Individual intolerance to the drug, ileus, gastrointestinal bleeding, galactosemia. It is undesirable to use the drug methenolone enanthate side effects in acute gastric ulcer and 12 duodenal ulcer, intestinal atony.

Dosing and Administration

Inside, if necessary – after the preliminary methenolone enanthate side effects grinding, drinking water, one hour before meals and taking other medicines:

  • adults and children over 12 years – 2 – 3 tablets 3 times per day,
  • Children 8 to 12 years – 1 – 2 tablets three times a day,
  • Children from 3 to 7 years – 1 tablet 3 times a day,
  • Children from 1 year to 3 years – V1 tablets 3 times a day,

 

The average duration of treatment – 2 – 3 weeks.

Long-term use of the drug and repeat courses methenolone enanthate side effects of treatment should be carried out only on a doctor’s recommendation.

Side effect

Allergic reactions to components of the drug, rare – bloating, diarrhea.

Overdose

Symptoms: constipation, abdominal pain. Treatment: discontinuation of the drug.

Interaction with other drugs

Perhaps the reduction in the therapeutic effect at the same time some of the ingested drugs.

special instructions

The drug can be used in combination therapy methenolone enanthate side effects in conjunction with other drugs with specified separate administration.

primobolan depot for sale

Lactobacilli has a high antagonistic primobolan depot for sale activity against pathogenic and opportunistic bacteria, including Staphylococcus, enteropathogenic Escherichia coli, Proteus, which determines the correcting effect of the drug in violation bacteriocenosis. The drug improves metabolism, prevents the primobolan depot for sale formation of lingering forms of intestinal disease, raises nonspecific resistance of the organism.Treatment of patients with vaginal dysbiosis and non-specific inflammation of the vagina.
– Colpites (except gonorrhea, trichomoniasis and Candida etiology) – the drug is prescribed as an independent agent or after the course of antibiotic therapy;
– dysbiosis vagina accompanying inflammatory cervical processes of the body and the uterus – after the course of antibiotic therapy;
– preparation for the planned gynecological surgery to prevent postoperative infectious complications;
– antenatal preparation of pregnant primobolan depot for sale women at risk for the development of septic complications.

Dosage and Administration .
Before intravaginal suppository with the packaging material is removed.
– In the treatment of dysbiosis and kolpitov laktobakterin vagina appoint 1-2 suppository 1 time per day for 5-8 days under the control of vaginal secretion purity restoration to I-II degree and the disappearance of the clinical symptoms of inflammation (if necessary, the course may be extended to 10-12 days).
– in order to prevent septic complications primobolan depot for sale use 1 suppository 1 time per day for 5-7 days prior to the proposed transaction or delivery.
Application laktobakterina, suppositories vaginal is not recommended to be combined with simultaneous local administration of antibacterial agents.

primobolan depot side effects

Is recommended as a dietary food supplement – an additional source of the enzyme lactase.The enzyme lactase breaks down primobolan depot side effects and provides the disaccharide lactose absorption from food (often in the milk and milk products). Deficiency of the enzyme lactase can be congenital (primary lactase deficiency) or acquired (secondary lactase deficiency) occurs against a background primobolan depot side effects of infectious, immune, inflammatory and atrophic changes in the intestine. In the case of deficiency of the enzyme when consuming foods containing lactose, the symptoms of digestive disorders develop: bloating, diarrhea, intestinal spasms.

The use of the enzyme lactase primobolan depot side effects helps digest breast milk more efficiently, without interrupting breastfeeding, and allows full use of dairy products in the child’s diet.

Dosing
The recommended dosage for children under years – one capsule per feeding.

Children under one year who are breastfed – before each breastfeeding in 30 ml pre-expressed breast milk are added contents of the capsule, in a few minutes give the baby a bottle primobolan depot side effects fermented milk, and then finish feeding breast.

Children up to 1 year, are formula-fed, – the contents of the capsule add milk supply portion (1 capsule per 100 ml milk). Feeding start in a few minutes.

Children from 1 year to 5 years – the contents of 1-5 capsules (depending on the amount of milk) add to unheated (below + 55 ° C) food containing milk.

Children from 5 to 7 years – 2-7 capsules (depending on the amount of milk), if the child is unable to swallow primobolan depot side effects capsule or capsule contents with 2-7 unheated food containing milk.

methenolone enanthate

Can be administered to women during lactation, as well as contraindications to estrogen or unwillingness to use estrogensoderzhaschie kontraptsetivy. Unlike other progestin contraceptives, the contraceptive effect of the drug methenolone enanthate is due to inhibition of ovulation process, as evidenced by the absence of ovulatory follicle on ultrasound and the absence of increasing values luteotrophic hormone , and progesterone in the blood serum in the middle of the menstrual cycle. At the same time, desogestrel, also. Like other progestogens, has the property to increase the viscosity of the cervical mucus, preventing sperm promotion. Pearl Index (an indicator of the onset of pregnancy in 100 women during a year of contraception) is 0.4, which is comparable with the use of combined hormonal contraceptives for oral use. Use of the drug methenolone enanthate leads to a decrease of estradiol in the blood plasma to a value corresponding to the early follicular phase. Progestogens affect the carbohydrate and lipid metabolism. Absorption When administered desogestrel is rapidly absorbed. The average maximum serum concentration achieved after 1.8 hours  after administration of the tablet. Etonogestrel bioavailability is about. The distribution in the body of etonogestrel in  bound to plasma proteins, mainly to albumin and to a lesser extent with binding globulin sex hormones (SHBG). Metabolism Desogestrel by dehydrogenation and hydroxylation metabolized to the active metabolite etonogestrel. Etonogestrel is metabolized through the formation of sulfate and glucuronide conjugates.

 

 

Contraindications

  • Currently presence or history of venous thromboembolic events (including deep vein thrombosis of the lower extremities, pulmonary embolism;
  • severe liver disease, current or history (up to normalization of liver function);
  • liver failure current or history;
  • established or suspected methenolone enanthate hormone-dependent malignant tumors (including breast cancer);
  • liver cancer;
  • vaginal bleeding of unknown etiology;
  • established or suspected pregnancy;
  • Hypersensitivity to desogestrel or any other component of the formulation.
  • lactose intolerance, lactase deficiency, glucose-galactose malabsorption;
  • prolonged immobilization, including associated with surgery or disease (risk of venous thromboembolism).

Carefully

  • resistant hypertension. developing on the background of the drug, including the ineffectiveness of antihypertensive therapy;
  • chloasma, especially in the presence of chloasma during pregnancy in history;
  • diabetes mellitus (due to the possible influence on the peripheral nnsulinrezistentnost progestogens and glucose tolerance);
  • porphyria;
  • Systemic lupus erythematosus (SLE);
  • herpes (during pregnancy in history).

Pregnancy and lactation Pregnancy During methenolone enanthate pregnancy, the use of the drug is contraindicated. In preclinical studies. the introduction of very high doses of progestogen observed masculinization of female fetuses. Epidemiological studies have revealed no increased risk of teratogenic effects and birth defects in children whose mothers took oral hormonal contraceptives prior to pregnancy or unintentionally – in the early stages of pregnancy. Lactation As with other drugs containing progestogen only, Laktinet ® does not affect the quality and quantity of breast milk, but a small amount of a metabolite of desogestrel (etonogestrel) is excreted in breast milk and is approximately 0.01-0.05 mg / kg / day (when the amount of intake of breast milk 150 ml / kg / day). The results of 7-month follow-up revealed no elevated risks for children who are breastfed in the assessment of their growth, psychomotor and physical development. However, the need to carefully monitor the dynamic development and growth of the baby during breastfeeding if a woman for the purpose of contraception using a drug methenolone enanthate .

 

Dosing and Administration
In the absence of prior use of hormonal contraceptives (within the last month) reception of tablets start from the first day of the menstrual cycle, one tablet per day, if possible at one and the same time of day, following in the indicated on the packaging direction to the break between intake of two tablets was 24 hours, if necessary with a small amount of liquid. This drug does not require a break in the reception. Every next pack should be started immediately after the previous one. The first appointment of the drug women, who in the previous month did not take oral kontratseptivov : Receiving the first tablet should be started from the first day of the menstrual cycle (menstruation). In this case, do not need to use additional contraceptive methods. Tablets Admission can start with 2-5 days of menstruation, but in this case in the first cycle it is necessary to use additional methods of contraception during the first 7 days of receiving pills. Women who switch from another combined oral contraceptive (CPC) at Laktinet ® If possible, the next day after taking the last tablet of the previous handheld. In this case, it does not require the use of additional methods of contraception. Women who switch from monocomponent preparations containing only progestogen (mini-pill, injection, implant or IUD, releasing progestogen) During the transition from mini-pill the drug, you can start on any day ; in the case of injection – on a day when should be methenolone enanthate done next injection; in the case of the implant -. a day after his removal In all these cases, we recommend the use of barrier methods of contraception during the first 7 days. Acceptance of the drug after an abortion in the first trimester of pregnancy, after abortion in the first trimester of taking the drug pregnancy is recommended to start immediately after abortion, and this case, there is no need to use additional contraceptive methods. Receiving the drug after delivery or after abortion in the second trimester of the drug is not an early start 21-28 days after the termination of pregnancy in the second trimester or after delivery. If you start taking the drug suggest later, you should use a barrier method of contraception for the first 7 days. In addition, if prior to the start of the drug have been unprotected sex, it is necessary to exclude pregnancy or postpone the beginning of the drug is on the first day of the next menstruation (the reduction of the menstrual cycle). Missed (neglected) pill contraceptive effectiveness is reduced if between taking two tablets have passed over 36 hours. If a break not exceeding 12 hours , the contraceptive effect is not reduced, and the use of an additional contraceptive method is not required. Admission remaining tablets continue on the regular schedule. In the case of more than 12-hour break , the contraceptive effect may be reduced. In order to achieve an effective blocking of the hypothalamic-pituitary -yaichnikovoy system needs to take the drug every day for 7 days. Thus, when a break of greater than 12 hours , taking the drug continues as usual, but in the next 7 days is necessary to use an additional (barrier) methods of contraception. If the reception of the tablet was missed in the first week of the drug in the previous 7 days had unprotected sexual intercourse, it is impossible to exclude the possibility of pregnancy. Measures taken in case of vomiting If within 3-4 hours after taking the pill develop vomiting, the pill is absorbed incompletely. In this case, you should do the same as in the case of missed pills. The desired tablet (tablets needed) should fill from a new package. Observation Although the regular intake of tablets, there can be a violation of menstruation. If menstruation occur very often and regularly, you should consider using another method of contraception. If the disorder is stored, it is necessary to exclude an organic cause. Management of the arisen during the application of the drug amenorrhea depends on whether the pill according to the instructions or not accepted; may require a pregnancy test. If there is a pregnancy, the drug should be stopped. It must be remembered that taking methenolone enanthate drug does not protect against HIV infection (AIDS) and other diseases, sexually transmitted diseases.

 

Side effects
The most common adverse effect reported in clinical studies were irregular menstruation. Up to 50% of women using desogestrel, noted acyclic spotting: 20-30% of menstruating women are becoming more frequent, while in the other 20% – a rare or even may stop. Menses may also be longer.
After several months of ingestion, menses tend to become less frequent. Informing clinicians, medical supervision, as well as the use of menstrual diary can improve the compliance of drug treatment.
The following are the unwanted effects that have established, probable or possible link to the use of the drug.
In that case, if there is any of the following conditions / risk factors need to be carefully weighed the expected benefits and risks of the contraceptive in consultation with the doctor methenolone enanthate during the whole period of contraception. When prompted, strengthen, change any of the following conditions / risk factors, the patient should immediately consult your doctor to decide on the possibility of further use of the drug.
Often, acne, nausea, mood changes, decreased libido, breast tenderness, menstrual disorders, headache pain, weight gain.
Uncommon: alopecia, fatigue, vomiting, discomfort while wearing contact lenses, vaginitis, dysmenorrhea, ovarian cyst.
rare: skin redness, rash, urticaria, erythema nodosum.
Although a significant association with the intake of progestogens has not been established, with their reception possible cholestatic jaundice, pruritus, cholelithiasis, chorea, herpes gestationis, otosclerosis, hearing loss, development of hemolytic-uremic syndrome.

Overdose
Overdose Symptoms: nausea, vomiting, spotting / bleeding from the vagina. No specific antidote, treatment is symptomatic.

Interaction with other medicinal products
Concomitant use of drugs, inducers of microsomal liver enzymes, can cause breakthrough bleeding and reducing the contraceptive effect. Such drugs are hydantoin derivatives (including phenytoin), rifabutin, barbiturates, primidone, carbamazepine and rifampicin and oxcarbazepine, topiramate. felbamate and griseofulvin. Specialized studies for desogestrel interactions with other drugs have not been conducted.Maximum induction of microsomal liver enzymes is achieved no earlier than 2-3 weeks. after the start of the corresponding inducer up to 4 weeks. after its cancellation.
Antibiotics (eg., ampicillin and tetracycline) reduce the effectiveness perorapnyh contraception.
Women taking drugs that induce microsomal liver enzymes should be advised to use an additional temporary barrier or other non-hormonal contraceptive methods.
In an application. the above drugs with desogestrel, it is recommended to use a barrier method of contraception during treatment and for 7 days (for rifampicin – 28 days). after the end of therapy
in the treatment of activated carbon absorption of steroids and hence, and contraceptive efficacy may be reduced. In this case, you should follow the advice given in section “Dosage and administration” on missed receiving the drug.

Cautions
If you have any condition or risk factor, the doctor must correlate the risks and benefits of the drug Laktinet ® individually for each woman prior to the start of hormonal contraception. In case of any undesirable effect or risk factor you must immediately put the doctor in popularity for a decision on whether to continue taking the drug.
Women with diabetes should be under careful surveillance during the first months of use Laktinet ® .
Reception Laktinet ® reduces the estradiol serum to a value corresponding to the early follicular phase.
the protective effect of traditional only progestagensoderzhaschih contraceptives in terms of ectopic pregnancy prevention is not as pronounced as that of combined oral contraceptives, which is associated with relatively often occurring in patients receiving only progestagensoderzhaschih preparations ovulation.
Despite the fact that Laktinet ® , usually inhibits ovulation, the possibility of an ectopic pregnancy should be borne in mind in the differential diagnosis in the development of women in amenorrhea or abdominal pain.
chloasma may occur sometimes, especially in women with a history of chloasma pregnant. Women with a tendency to chloasma should avoid sunlight and ultraviolet radiation while taking Laktinet ® .
Patients with lactose intolerance should be borne in mind that one film-coated tablet Laktinet ® contains 67.445 mg of lactose monohydrate. Patients with rare hereditary conditions such as lactose intolerance, lactase deficiency or glucose-galactose malabsorbtsiey should not take the drug.